- Introduction: Understanding Trisomy 21 in a New Era
- Part 1: The Evolving Lifespan and Health Landscape
- Chapter 1: Increased Longevity and Its Implications
- Chapter 2: Navigating Age-Related Health Considerations
- Chapter 3: Mental Health and Well-Being in Trisomy 21
- Chapter 4: Trisomy 21 Regression Disorder (DSRD)
- Part 2: Foundations for Flourishing
- Chapter 5: The Critical Role of Early Intervention
- Chapter 6: Achieving True Inclusive Education
- Part 3: Expanding Horizons
- Chapter 7: Landmark Research and the Future of T21 Science
- Chapter 8: The Movement Toward Self-Determination
- Chapter 9: Personalized Approaches in Therapy and Lifelong Support
- Part 4: Technology as an Ally
- Chapter 10: Assistive Technology and Communication Supports
- Chapter 11: Telehealth and Remote Access to Services
- Chapter 12: The Transformative Potential of Artificial Intelligence
- Part 5: Navigating Life
- Chapter 13: For Individuals with Trisomy 21
- Chapter 14: For Families
- Chapter 15: For Care Providers
- Part 6: Synthesizing the Journey
- Chapter 16: Addressing Systemic Challenges and Emerging Issues
- Conclusion: A Unified and Hope-Centered Future
- Appendix A: Glossary of Terms
- Appendix B: Key Organizations and Resources
Trisomy 21 in the 21st Century
Navigating Challenges, Embracing Innovations, and Empowering Lives
A comprehensive, research-informed framework examining Down syndrome through the lens of 21st-century medicine, technology, and evidence-based care. This working edition invites clinical dialogue on emerging therapies, AI applications, and lifespan considerations for the T21 community.
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Trisomy 21 in the 21st Century: Navigating Challenges, Embracing Innovations, and Empowering Lives presents a comprehensive, evidence-based framework for understanding Down syndrome in our rapidly evolving healthcare and technology landscape.
This working edition synthesizes current clinical research, emerging therapeutic approaches, and AI-enhanced data analysis to provide healthcare professionals, researchers, and interdisciplinary teams with a foundational reference. Drawing from peer-reviewed literature, clinical guidelines, and stakeholder interviews, it addresses the full lifespan continuum—from early intervention through aging-related considerations including the T21-Alzheimer's connection.
Beyond traditional clinical perspectives, this framework integrates family experiences, educational innovations, and technological advances to support evidence-based decision-making. We seek feedback from the medical and research community to refine future editions and strengthen clinical utility.
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