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Toxicokinetic-toxicodynamic (TKTD) modelling has been my research topic (and passion) since 2002. Over the years, I realised that there were many things that I wanted (or needed) to know that were still unknown. Furthermore, I realised that answering these questions was, in many cases, not easy at all (especially for a theoretician with no access to a lab). Here these questions are bundled together to, hopefully, inspire a new generation of ecotoxicologists to address these fundamental scientific questions about the mechanistics underlying the response to toxicants (and some practical issues as well).

To fully appreciate these questions, you should have a firm grip on the concepts of TKTD modelling in general, and the concepts underlying GUTS and DEBtox in particular. These topics are only very briefly introduced in this book; much more thorough introductions are provided in my other e-books. This book is (for now) math-free. I guess this is not a book that you would want to read from front to back; it is probably more for browsing and selecting particular sections to read.

The questions are grouped in chapters. Each chapter starts with a short introduction. Each section within each chapter deals with an open question (or topic of research), and references are provided at the end of each section. Each section is rather short (I aim for a maximum of two pages, including a figure and references), so each discussion is rather superficial. The references given provide more details (and more references to consider).

Support page at debtox.info (includes a version log)

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Kick off your book project, get started with GhostAI, get better at marketing, or spend the day doing all three! Free live workshops on Zoom. Saturday, June 27, 2026.

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