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Finding Hidden Messages in DNA represents the first two chapters of Bioinformatics Algorithms: an Active Learning Approach, which is one of the first textbooks to emerge from the recent Massive Open Online Course (MOOC) revolution. A light-hearted and analogy-filled companion to the authors’ acclaimed MOOC on Coursera, this book presents students with a dynamic approach to learning bioinformatics. It strikes a unique balance between practical challenges in modern biology and fundamental algorithmic ideas, thus capturing the interest of students of both biology and computer science.

The two chapters cover two central biological questions: “Where in the Genome Does Replication Begin?” and “Which DNA Patterns Play the Role of Molecular Clocks?” The textbook then steadily develops the algorithmic sophistication required to answer each question. Dozens of exercises are incorporated directly into the text as soon as they are needed; readers can test their knowledge through automated coding challenges on the Rosalind Bioinformatics Textbook Track.

The textbook website augments the textbook by providing additional educational materials, including video lectures and PowerPoint slides.

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Kick off your book project in 3 hours! Live workshop on Zoom. You’ll leave with a real book project, progress on your first chapter, and a clear plan to keep going. Saturday, May 16, 2026. Learn more…

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