Making sense of chemical stress
Minimum price
Suggested price

Making sense of chemical stress

Application of Dynamic Energy Budget theory in ecotoxicology and stress ecology

About the Book

Have you ever asked yourself why the effects of toxic chemicals depend on the exposure time? Or asked why stress effects on growth and reproduction are so different in the same organism, even though these responses must be linked in some causal way? Did you ever wish to understand toxic effects, so that you can make an educated prediction of effects under other conditions? Or do you want to understand why toxic effects depend on other factors such as temperature, food density, and life stage? This book addresses those questions by taking a radically different approach than what is common in ecotoxicology and stress ecology: by simplifying biological reality to an enormous extent. In this book, I will present a mechanistic treatment of chemical effects. The main focus lies on one particularly useful framework for the interpretation of toxic effects, namely Dynamic Energy Budget (DEB) theory. Even if you are not convinced that this theory is the way to go for your particular problem, knowledge of the concepts behind it allows you to examine your (and other people's) data and models more critically. DEB theory is a powerful framework for ecotoxicology and stress ecology. This book provides a gentle introduction into the concepts behind the theory, and how to apply them in practice to understand stressor effects. The book is completely "math free", but all technicalities are available in (freely downloadable) documents on the support page.

Support page at (includes the version log)

About the Author

Tjalling Jager
Tjalling Jager

Mechanistic modelling is still an under-utilised tool in ecotoxicology and stress ecology. It is my passion to promote these models through (applied) scientific projects, providing software solutions, teaching in courses, presentations at conferences, and through writing e-books. The models that I specialise in are so-called toxicokinetic-toxicodynamic (TKTD) models; in particular, models for survival (the GUTS framework) and sublethal effects (based on Dynamic Energy Budget - DEB - theory). These models are based on a rigorous simplification of biological complexity, and have the power to explain (and predict) life-history traits of organisms (e.g., growth, reproduction and survival) over time. Especially when considering exposure to stressors, such dynamic models are indispensable to make sense of the data.

I hold an MSc and PhD in Biology, and have been a professional modeller since 1992, working almost exclusively on DEB- and GUTS-based TKTD modelling since 2002. Currently, I run my own private company 'DEBtox Research', offering my expertise to clients from industry, contract laboratories, and universities.

More information about Tjalling at DEBtox Research

More information about DEB(tox) and GUTS models

Table of Contents


1. Setting the scene

2. A model for energy budgets

3. The energy budget under stress

4. Toxicokinetics

5. Damage dynamics and reduced models

6. Multiple stress

7. Selecting and fitting models

8. Case studies

9. Final words



The Leanpub 60 Day 100% Happiness Guarantee

Within 60 days of purchase you can get a 100% refund on any Leanpub purchase, in two clicks.

Now, this is technically risky for us, since you'll have the book or course files either way. But we're so confident in our products and services, and in our authors and readers, that we're happy to offer a full money back guarantee for everything we sell.

You can only find out how good something is by trying it, and because of our 100% money back guarantee there's literally no risk to do so!

So, there's no reason not to click the Add to Cart button, is there?

See full terms...

80% Royalties. Earn $16 on a $20 book.

We pay 80% royalties. That's not a typo: you earn $16 on a $20 sale. If we sell 5000 non-refunded copies of your book or course for $20, you'll earn $80,000.

(Yes, some authors have already earned much more than that on Leanpub.)

In fact, authors have earnedover $13 millionwriting, publishing and selling on Leanpub.

Learn more about writing on Leanpub

Free Updates. DRM Free.

If you buy a Leanpub book, you get free updates for as long as the author updates the book! Many authors use Leanpub to publish their books in-progress, while they are writing them. All readers get free updates, regardless of when they bought the book or how much they paid (including free).

Most Leanpub books are available in PDF (for computers) and EPUB (for phones, tablets and Kindle). The formats that a book includes are shown at the top right corner of this page.

Finally, Leanpub books don't have any DRM copy-protection nonsense, so you can easily read them on any supported device.

Learn more about Leanpub's ebook formats and where to read them

Write and Publish on Leanpub

You can use Leanpub to easily write, publish and sell in-progress and completed ebooks and online courses!

Leanpub is a powerful platform for serious authors, combining a simple, elegant writing and publishing workflow with a store focused on selling in-progress ebooks.

Leanpub is a magical typewriter for authors: just write in plain text, and to publish your ebook, just click a button. (Or, if you are producing your ebook your own way, you can even upload your own PDF and/or EPUB files and then publish with one click!) It really is that easy.

Learn more about writing on Leanpub